Abstract: Objective  To describe the status of the bi-directional screening model for Mycobacterium tuberculosis(Mtb) and human immunodeficiency virus(HIV)/AIDS infection in Hefei city, and to provide the scientific evidence for prevention and control of tuberculosis(TB) and HIV co-infection.  Methods  One thousand four hundred and twenty-two HIV/AIDS patients were screened for Mtb in 2011—2013 in Hefei, and 5772 newly registered TB patients were screened for the HIV antibody. All statistical analyses were performed using SPSS 21.0 statistical software, and Chi-square test was used for categorical variables, 0.05 was set as the criteria of statistical significance.  Results  During 2011—2013, the TB screening rates among HIV/AIDS patients were 92.62%(276/298), 99.57%(458/460) and 98.29%(688/700) respectively, with significant increasing trend (χ²_trend=18.57, P<0.001). During 2011—2013, the HIV screening rate of registered TB patients were 40.17%(1701/4234), 38.20%(1632/4272) and 53.49%（2439/4560） respectively, which showed the significant increasing trend as well (χ²_trend=162.83, P<0.001). The HIV antibody screening rate in new TB control network areas was 60.99%(2029/3327), which was significantly higher than other areas（33.25%，410/1233）(χ²=1083.62, P<0.001).  Conclusion  The bi-directional screening for Mtb and HIV is the main route to detect Mtb/HIV co-infection patients, accordingly，actively carrying out the screening work has important implications for improving the detection rate of co-infection, effective control of Mtb/HIV co-infection, improving the quality of life and mortality of co-infected patients.

Key words: Tuberculosis, Acquired immunodeficiency syndrome, Superinfection, Mass screening, Hefei city